Make the Diagnosis: Generalized Anxiety or Panic Disorder
Anxiety symptoms are ubiquitous. Generalized anxiety (GAD) and panic disorders are much less common. The community lifetime prevalence of GAD is 5.1%, and for panic disorder it is 3.5%. Over a 12-month period, about 3.1% of patients in the community will develop GAD and 2.3% will develop a panic disorder.1
Generalized Anxiety Prior Probability |Favorite Table|Download (.pdf) Generalized Anxiety Prior Probability
|Generalized Anxiety ||Prior Probability ||Useful Findings for Diagnosing Generalized Anxiety or Panic Disorders ||Disorder ||Score Threshold ||LR+ (95% CI) ||LR−(95% CI) |
| ||The community lifetime prevalence of generalized anxiety disorder (GAD) is 5.1%, and for panic disorder it is 3.5%. Over a 12-month period, about 3.1% of patients in the community will develop GAD and 2.3% will develop a panic disorder. ||Generalized Anxiety Disorder Scale 7 Item ||Generalized anxiety disorder ||≥ 10 vs < 10 ||5.1 (4.3-6.0) ||0.13 (0.07-0.26) |
|Patient Health Questionnaire, panic module ||Panic disorder ||5 vs < 5 ||78 (29-210) ||0.20 (0.11-0.37) |
Population for Whom Generalized Anxiety and Panic Disorder Should Be Considered
Many patients present to their primary care clinician with somatic complaints, leading to costly diagnostic testing to rule out underlying pathologic illness. Among patients who present with a specific concern of anxiety, 22% may have GAD.2,3 Generalized anxiety disorder should be considered when patients seem excessively worried and have trouble controlling their worry, with somatic symptoms such as restlessness, easy fatigability, irritability, difficulty concentrating, muscle tension, or sleep disturbance. Panic disorder should be considered when patients have unexpected and unprovoked attacks of fear that occur repeatedly.
Assessing the Likelihood of Generalized Anxiety or Panic Disorder
The best measures for assessing the likelihood of these disorders are through patient self-report, prompted by clinician administered questionnaires (see Table 95-1) and clinical assessment. The Generalized Anxiety Disorder Scale 7 Item (GAD-7) evaluates symptoms during the prior 2 weeks and asks about the presence of 7 different symptoms that are self-assessed as not at all present, present for several days, present for more than half the days, or present nearly every day.4 The Patient Health Questionnaire (PHQ) panic module includes only 5 questions (the fifth question has 11 subitems), although if the answer to the first question is "no," the remaining questions 2-5 may be skipped. The PHQ can be completed by patients with low literacy and requires < 1 minute for completion.5 These questionnaires are available online (www.phqscreeners.com).
Table 95-1.Useful Findings for Diagnosing Generalized Anxiety or Panic Disorders |Favorite Table|Download (.pdf) Table 95-1. Useful Findings for Diagnosing Generalized Anxiety or Panic Disorders
|Scale ||Disorder ||Score Threshold ||LR+ (95% CI) ||LR− (95% CI) |
|Generalized Anxiety Disorder Scale 7 Item ||Generalized anxiety disorder ||≥ 10 vs < 10 ||5.1 (4.3-6.0) ||0.13 (0.07-0.26) |
|Patient Health ...|
Log In to View More
If you don't have a subscription, please view our individual subscription options below to find out how you can gain access to this content.
Want remote access to your institution's subscription?
Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.
If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.
JAMAevidence Full Site: One-Year Subscription
Connect to the full suite of JAMAevidence content and resources including interactive self-assessment, videos, and more.
Pay Per View: Timed Access to all of JAMAevidence
24 Hour Subscription $34.95
48 Hour Subscription $54.95
Pop-up div Successfully Displayed
This div only appears when the trigger link is hovered over.
Otherwise it is hidden from view.