TY - CHAP M1 - Book, Section TI - Discrimination and Calibration of Clinical Prediction Models A1 - Alba, Ana Carolina A1 - Agoritsas, Thomas A1 - Walsh, Michael A1 - Hanna, Steven A1 - Iorio, Alfonso A1 - Devereaux, P. J. A1 - McGinn, Thomas A1 - Guyatt, Gordon A2 - Guyatt, Gordon A2 - Rennie, Drummond A2 - Meade, Maureen O. A2 - Cook, Deborah J. PY - 2015 T2 - Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed AB - You are a general internist seeing an ambulatory consult. This new patient is a 54-year-old male with a history of hypertension treated with calcium channel blockers. He smokes and has a sedentary lifestyle but has not had any previous cardiovascular events. What is the risk of a cardiovascular event for this patient? Recent laboratory results show normal levels of total cholesterol (198 mg/dL) and low-density lipoprotein cholesterol (138 mg/dL), but a decreased level of high-density lipoprotein cholesterol (39 mg/dL). On physical examination, his systolic and diastolic blood pressure is 130 mm Hg and 80 mm Hg, respectively. Based on this information and using an online tool (Pooled Cohort Equations [modified from the Framingham risk score, which is recommended by the American Heart Association]), you calculate his risk of a cardiovascular event (myocardial infarction, stroke, or death due to coronary artery disease) to be 12.4% at 10 years.1 Given this risk, current US, European, and Canadian guidelines recommend smoking cessation, regular physical activity, and initiation of statin therapy for primary prevention.2 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - jamaevidence.mhmedical.com/content.aspx?aid=1183877724 ER -