TY - CHAP M1 - Book, Section TI - How to Use a Noninferiority Trial A1 - Mulla, Sohail M. A1 - Scott, Ian A. A1 - Jackevicius, Cynthia A. A1 - You, John J. A1 - Guyatt, Gordon A2 - Guyatt, Gordon A2 - Rennie, Drummond A2 - Meade, Maureen O. A2 - Cook, Deborah J. PY - 2015 T2 - Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed AB - Traditionally, randomized clinical trials (RCTs) have sought to ascertain whether an experimental treatment is superior to standard treatment or placebo in improving quality of life or preventing morbid or mortal events—what we will refer to as effectiveness outcomes. In these superiority trials, the primary objective is to determine the magnitude of increased benefit of the experimental intervention over standard therapy on effectiveness outcomes. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - jamaevidence.mhmedical.com/content.aspx?aid=1183875813 ER -