TY - CHAP M1 - Book, Section TI - Surprising Results of Randomized Trials A1 - Brignardello-Petersen, Romina A1 - Ioannidis, John P. A. A1 - Tomlinson, George A1 - Guyatt, Gordon A2 - Guyatt, Gordon A2 - Rennie, Drummond A2 - Meade, Maureen O. A2 - Cook, Deborah J. Y1 - 2015 N1 - T2 - Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed AB - Ideally, evidence for the effectiveness of diagnostic, preventive, or therapeutic interventions will come from rigorous randomized clinical trials (RCTs) measuring effects on patient-important outcomes, such as stroke, myocardial infarction, and death. Whenever an intervention is tested to see whether it is effective for patient-important outcomes, typically some other evidence of variable quantity and quality already exists. This evidence includes combinations of basic science findings, preclinical results, observational studies, and phase 1 or 2 clinical trials. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2023/11/30 UR - jamaevidence.mhmedical.com/content.aspx?aid=1183875951 ER -