TY - CHAP M1 - Book, Section TI - N-of-1 Randomized Clinical Trials A1 - Guyatt, Gordon A1 - Zhang, Yuqing A1 - Jaeschke, Roman A1 - McGinn, Thomas A2 - Guyatt, Gordon A2 - Rennie, Drummond A2 - Meade, Maureen O. A2 - Cook, Deborah J. Y1 - 2015 N1 - T2 - Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed AB - Clinicians should use the results of randomized clinical trials (RCTs) of groups of patients to guide their clinical practice. When deciding which management approach will be best for an individual patient, however, clinicians cannot always rely on the results of RCTs. An RCT that addresses the particular issue may not be available; for example, some conditions are so rare that randomized trials are not feasible. Furthermore, even when a relevant RCT generates a clear answer, its result may not apply to an individual patient. First, if the patient is very different from trial participants, the trial results may not be applicable to that patient (see Chapter 13.1, Applying Results to Individual Patients). Second, regardless of the overall trial results, some similar patients may benefit from a given therapy, whereas others receive no benefit. Clinicians may have particularly strong reservations about applying RCT results to individuals when results have revealed small treatment effects of questionable importance. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/04 UR - jamaevidence.mhmedical.com/content.aspx?aid=1183876098 ER -