TY  - CHAP
M1  - Book, Section
TI  - N-of-1 Randomized Clinical Trials
A1  - Guyatt, Gordon
A1  - Zhang, Yuqing
A1  - Jaeschke, Roman
A1  - McGinn, Thomas
A2  - Guyatt, Gordon
A2  - Rennie, Drummond
A2  - Meade, Maureen O.
A2  - Cook, Deborah J.
Y1  - 2015
N1  - 
T2  - Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed
AB  - Clinicians  should  use  the  results  of  randomized  clinical  trials  (RCTs)  of  groups  of  patients  to  guide  their  clinical  practice.  When  deciding  which  management  approach  will  be  best  for  an  individual  patient,  however,  clinicians  cannot  always  rely  on  the  results  of  RCTs.  An  RCT  that  addresses  the  particular  issue  may  not  be  available;  for  example,  some  conditions  are  so  rare  that  randomized  trials  are  not  feasible.  Furthermore,  even  when  a  relevant  RCT  generates  a  clear  answer,  its  result  may  not  apply  to  an  individual  patient.  First,  if  the  patient  is  very  different  from  trial  participants,  the  trial  results  may  not  be  applicable  to  that  patient  (see  Chapter  13.1,  Applying  Results  to  Individual  Patients).  Second,  regardless  of  the  overall  trial  results,  some  similar  patients  may  benefit  from  a  given  therapy,  whereas  others  receive  no  benefit.  Clinicians  may  have  particularly  strong  reservations  about  applying  RCT  results  to  individuals  when  results  have  revealed  small  treatment  effects  of  questionable  importance.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/20
UR  - jamaevidence.mhmedical.com/content.aspx?aid=1183876098
ER  -