TY - CHAP M1 - Book, Section TI - How to Use an Article About Genetic Association A1 - Holliday, Elizabeth G. A1 - Ioannidis, John P. A. A1 - Thakkinstian, Ammarin A1 - McEvoy, Mark A1 - Scott, Rodney J. A1 - Minelli, Cosetta A1 - Thompson, John A1 - Infante-Rivard, Claire A1 - Guyatt, Gordon A1 - Attia, John A2 - Guyatt, Gordon A2 - Rennie, Drummond A2 - Meade, Maureen O. A2 - Cook, Deborah J. PY - 2015 T2 - Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed AB - This chapter is a guide for clinicians using genetic association studies to inform their clinical practice. In this chapter, which is restricted to genetic association studies and does not deal with other types of designs, such as genetic linkage studies, we begin by summarizing the key concepts in genetics that are the necessary basis for understanding genetic association studies. We then introduce the idea of genetic association for both single-candidate gene and genome-wide association studies (GWASs). We use the APOE gene polymorphism and its association with Alzheimer disease as a case study to demonstrate the concepts and introduce the terms used in this field. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/09 UR - jamaevidence.mhmedical.com/content.aspx?aid=1183877650 ER -