TY - CHAP M1 - Book, Section TI - Assessing the Strength of Recommendations: The GRADE Approach A1 - Neumann, Ignacio A1 - Akl, Elie A. A1 - Vandvik, Per Olav A1 - Alonso-Coello, Pablo A1 - Santesso, Nancy A1 - Murad, M. Hassan A1 - Spencer, Frederick A1 - Schünemann, Holger J. A1 - Guyatt, Gordon A2 - Guyatt, Gordon A2 - Rennie, Drummond A2 - Meade, Maureen O. A2 - Cook, Deborah J. PY - 2015 T2 - Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed AB - CLINICAL SCENARIOYou are a primary care practitioner considering the possibility of the use of aspirin for primary prevention of serious cardiovascular events and cancer in a 60-year-old man. He has hypertension, adequately controlled with thiazides, but he is otherwise healthy; he does not have diabetes or dyslipidemia, does not smoke, and has no family history of heart disease.To inform your decision, you search first for an evidence-based recommendation and find the following: “In many adults, the benefits of aspirin exceed the risks (principally bleeding). For individuals 50 years or older without excess bleeding risk, we suggest low-dose daily aspirin (75-100 mg) (weak recommendation based on moderate confidence in effect estimates).”1After reading the corresponding Users' Guide (see Chapter 26, How to Use a Patient Management Recommendation: Clinical Practice Guidelines and Decision Analyses), you know that weak recommendations reflect the judgment of a specific group (eg, a guideline panel) that an individualized decision is necessary. You are curious, however, about the rationale for a weak recommendation for aspirin use and decide that this is a good opportunity to understand more about the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach to move from evidence to recommendations. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - jamaevidence.mhmedical.com/content.aspx?aid=1183878256 ER -