TY - CHAP M1 - Book, Section TI - TABLE: Levels of Evidence A1 - Simel, David L. A1 - Rennie, Drummond PY - 2016 T2 - The Rational Clinical Examination: Evidence-Based Clinical Diagnosis AB - Table Graphic Jump LocationLevels of EvidenceaView Table||Download (.pdf)Levels of EvidenceaLevel of EvidenceGradeDefinition1AIndependent blinded comparison of sign or symptom results with a criterion standard of diagnosis among a large number of consecutive patients suspected of having the target condition2BIndependent blinded comparison of sign or symptom with a criterion standard of diagnosis among a small number of consecutive patients suspected of having the target condition3CIndependent blinded comparison of sign or symptom with a criterion standard of diagnosis among nonconsecutive patients suspected of having the target condition4CNonindependent comparison of sign or symptom with a criterion standard of diagnosis among samples of patients who obviously have the target condition plus, perhaps, normal individuals5CNonindependent comparison of sign or symptom with a standard of uncertain validityaModified from Holleman and Simel.13 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - jamaevidence.mhmedical.com/content.aspx?aid=3492931 ER -