RT Book, Section
A1 Alba, Ana Carolina
A1 Agoritsas, Thomas
A1 Walsh, Michael
A1 Hanna, Steven
A1 Iorio, Alfonso
A1 Devereaux, P. J.
A1 McGinn, Thomas
A1 Guyatt, Gordon
A2 Guyatt, Gordon
A2 Rennie, Drummond
A2 Meade, Maureen O.
A2 Cook, Deborah J.
SR Print(0)
ID 1183877724
T1 Discrimination and Calibration of Clinical Prediction Models
T2 Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-179071-0
LK jamaevidence.mhmedical.com/content.aspx?aid=1183877724
RD 2024/04/19
AB You  are  a  general  internist  seeing  an  ambulatory  consult.  This  new  patient  is  a  54-year-old  male  with  a  history  of  hypertension  treated  with  calcium  channel  blockers.  He  smokes  and  has  a  sedentary  lifestyle  but  has  not  had  any  previous  cardiovascular  events.  What  is  the  risk  of  a  cardiovascular  event  for  this  patient?  Recent  laboratory  results  show  normal  levels  of  total  cholesterol  (198  mg/dL)  and  low-density  lipoprotein  cholesterol  (138  mg/dL),  but  a  decreased  level  of  high-density  lipoprotein  cholesterol  (39  mg/dL).  On  physical  examination,  his  systolic  and  diastolic  blood  pressure  is  130  mm  Hg  and  80  mm  Hg,  respectively.  Based  on  this  information  and  using  an  online  tool  (Pooled  Cohort  Equations  [modified  from  the  Framingham  risk  score,  which  is  recommended  by  the  American  Heart  Association]),  you  calculate  his  risk  of  a  cardiovascular  event  (myocardial  infarction,  stroke,  or  death  due  to  coronary  artery  disease)  to  be  12.4%  at  10  years.1  Given  this  risk,  current  US,  European,  and  Canadian  guidelines  recommend  smoking  cessation,  regular  physical  activity,  and  initiation  of  statin  therapy  for  primary  prevention.2