RT Book, Section A1 Brignardello-Petersen, Romina A1 Carrasco-Labra, Alonso A1 Guyatt, Gordon H. A2 Guyatt, Gordon A2 Rennie, Drummond A2 Meade, Maureen O. A2 Cook, Deborah J. SR Print(0) ID 1191942955 T1 How to Interpret and Use a Clinical Practice Guideline or Recommendation T2 Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 978-0-07-179071-0 LK jamaevidence.mhmedical.com/content.aspx?aid=1191942955 RD 2024/04/24 AB CLINICAL SCENARIOA family physician is seeing a 25-year-old woman with seasonal allergic rhinitis. This year, her nasal and ocular symptoms are severe enough that she is seeking medical care. After the physician and patient discuss the treatment options, the physician initiates single therapy with an intranasal corticosteroid but is aware of an alternative treatment, an intranasal H1 antihistamine.To inform her decision, the physician searches for an evidence-based recommendation and finds the following: “In patients with seasonal allergic rhinitis, we suggest an intranasal corticosteroid rather than an intranasal antihistamine (conditional recommendation, moderate certainty of evidence).”1The physician explains to the patient that a conditional recommendation means that the therapy is likely to be the best choice, but because of the patient’s particular situation, it may not be. The physician prescribes an intranasal corticosteroid but explains that she will follow up with the patient with a telephone call after she reads further about this recommendation.