RT Book, Section A1 Marion, Joe D. A1 Althouse, Andrew D. A2 Livingston, Edward H. A2 Lewis, Roger J. SR Print(0) ID 1209449004 T1 Use of Historical Controls in Clinical Trials T2 JAMA Guide to Statistics and Methods YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781260455328 LK jamaevidence.mhmedical.com/content.aspx?aid=1209449004 RD 2024/10/06 AB This JAMA Guide to Statistics and Methods explains the use of historical controls—persons who had received a specific control treatment in a previous study—when randomizing participants to that control treatment in a subsequent trial may not be practical or ethical.