RT Book, Section A1 Dean, Natalie A1 Amin, Avnika B. A2 Livingston, Edward H. A2 Lewis, Roger J. SR Print(0) ID 1212552265 T1 Test-Negative Study Designs for Evaluating Vaccine Effectiveness T2 JAMA Guide to Statistics and Methods YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781260455328 LK jamaevidence.mhmedical.com/content.aspx?aid=1212552265 RD 2025/04/22 AB This JAMA Guide to Statistics and Methods article explains the test-negative study design, an observational study design routinely used to estimate vaccine effectiveness, and examines its use in a study that estimated the performance of messenger RNA boosters against the Omicron variant.