RT Book, Section A1 Djulbegovic, Benjamin A1 Guyatt, Gordon A2 Guyatt, Gordon A2 Rennie, Drummond A2 Meade, Maureen O. A2 Cook, Deborah J. SR Print(0) ID 1183875498 T1 Evidence-Based Medicine and the Theory of Knowledge T2 Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 978-0-07-179071-0 LK jamaevidence.mhmedical.com/content.aspx?aid=1183875498 RD 2024/04/25 AB Approaches to scientific inquiry—including evidence-based medicine (EBM)—depend on how one views the nature of knowledge as evidence, how it should be acquired, and how it should be applied (epistemology). The goal of this chapter is to make the EBM perspective on this issue—seldom clearly articulated—clearer. In this discussion, we highlight the 3 key principles of EBM (see Chapter 2, What Is Evidence-Based Medicine?).