RT Book, Section A1 McCaffery, Kirsten Jo A1 Jacklyn, Gemma Louise A1 Barratt, Alexandra A1 Brodersen, John A1 Glasziou, Paul A1 Carter, Stacy M. A1 Hicks, Nicholas R. A1 Howard, Kirsten A1 Irwig, Les A2 Guyatt, Gordon A2 Rennie, Drummond A2 Meade, Maureen O. A2 Cook, Deborah J. SR Print(0) ID 1183878449 T1 Recommendations About Screening T2 Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 978-0-07-179071-0 LK jamaevidence.mhmedical.com/content.aspx?aid=1183878449 RD 2023/03/26 AB CLINICAL SCENARIOYou are a primary care physician advising a 50-year-old woman who is concerned because a friend of hers was recently diagnosed as having breast cancer and has urged her to undergo mammography screening because “it's better to be safe than sorry.”The woman does not have a family history of breast or ovarian cancer or a breast lump. She asks whether you agree that she should undergo screening. You know that trials of mammography screening support both a mortality reduction from breast cancer and the existence of overdetection and false-positive results, which may result in unnecessary investigations and overtreatment. You are unsure of the magnitude of these effects, which you know are crucial in helping your patient to make her decision. To help, you need to know how screening can be evaluated, how screening test results should be interpreted, and whether there are any valid, relevant, and up-to-date clinical practice guidelines or recommendations about screening for breast cancer.