RT Book, Section A1 Simel, David L. A1 Rennie, Drummond SR Print(0) ID 3492931 T1 TABLE: Levels of Evidence T2 The Rational Clinical Examination: Evidence-Based Clinical Diagnosis YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071590303 LK jamaevidence.mhmedical.com/content.aspx?aid=3492931 RD 2024/04/23 AB Table Graphic Jump LocationLevels of EvidenceaView Table||Download (.pdf)Levels of EvidenceaLevel of EvidenceGradeDefinition1AIndependent blinded comparison of sign or symptom results with a criterion standard of diagnosis among a large number of consecutive patients suspected of having the target condition2BIndependent blinded comparison of sign or symptom with a criterion standard of diagnosis among a small number of consecutive patients suspected of having the target condition3CIndependent blinded comparison of sign or symptom with a criterion standard of diagnosis among nonconsecutive patients suspected of having the target condition4CNonindependent comparison of sign or symptom with a criterion standard of diagnosis among samples of patients who obviously have the target condition plus, perhaps, normal individuals5CNonindependent comparison of sign or symptom with a standard of uncertain validityaModified from Holleman and Simel.13