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A monthly series of discussions of core issues in evidence-based medicine by leading practitioners in the field.

Recorded and produced by JAMA editors for JAMAevidence, an innovative online resource for using evidence to improve care.

Listen on Apple Podcasts

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http://jamaevidenceusersguidemedicalliterature.jamanetwork.libsynpro.com/rss

http://jamaevidencerationalclinicalexamination.jamanetwork.libsynpro.com/rss

http://jamaevidencejamaguidetostatisticsandmethods.jamanetwork.libsynpro.com/rss

http://jamaevidencecareatthecloseoflife.jamanetwork.libsynpro.com/rss

Sections

Introduction to JAMAevidence

Users' Guides to the Medical Literature

The Rational Clinical Examination

JAMA Guide to Statistics and Methods

Care at the Close of Life

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Introduction to JAMAevidence: Drummond Rennie, MD, discusses the impetus and authorship behind JAMAevidence, which provides fundamental tools for dealing with the medical literature and making clinical diagnoses.

By Drummond Rennie, MD

8:02

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New! Thomas McGinn, MD, MPH, discusses the Users’ Guide on measuring agreement beyond chance.

By Thomas McGinn, MD, MPH

15:01

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Roman Jaeschke, MD, MSc, FRCPC, discusses the Users’ Guide on correlation and regression.

By Roman Jaeschke, MD, MSc, FRCPC

15:47

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Paul Moayyedi, BSc, MBChB, PhD, MPH, discusses the Users’ Guide for economic analysis.

By Paul Moayyedi, BSc, MBChB, PhD, MPH

25:44

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Victor M. Montori, MD, MSc, discusses the Users’ Guide for misleading presentations of clinical trial results.

By Victor M. Montori, MD, MSc

31:28

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Anne M. Holbrook, MD, PharmD, MSc, FRCPC, explains how to understand and assess surrogate outcomes when reviewing the medical literature.

By Anne M Holbrook, MD, PharmD, MSc, FRCPC

17:25

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Yun Liu, PhD, discusses how to read an article that uses machine learning.

By Yun Liu, PhD

25:28

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Victor M. Montori, MD, MSc, discusses decision making and the patient.

By Victor Montori, MD, MSc

20:46

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Thomas Agoritsas, MD, PhD, discusses how to apply results to individual patients.

By Thomas Agoritsas, MD, PhD

19:17

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Gordon Guyatt, MD, discusses how to use a subgroup analysis.

By Gordon Guyatt, MD

09:57

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Gordon Guyatt, MD, discusses composite end points.

By Gordon Guyatt, MD

23:32

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W. Scott Richardson, MD, discusses differential diagnosis.

By W. Scott Richardson, MD

24:48

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John Attia, MD, PhD, discusses how to use an article about genetic association.

By John Attia, MD, PhD

15:04

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George Tomlinson, PhD, discusses how to use an article about hypothesis testing and appropriate interpretation of P values.

By George Tomlinson, PhD

16:14

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Eddy Fan, MD, PhD, discusses how to use an article about quality improvement.

By Eddy Fan, MD, PhD

10:51

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Gordon Guyatt, MD, discusses network meta-analysis.

By Gordon Guyatt, MD

09:03

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Matthias Briel, MD, discusses the principle of intention to treat and ambiguous dropouts.

By Matthias Briel, MD

19:25

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Evidence-Based Medicine and the Theory of Knowledge: Interview With Dr Gordon Guyatt

By Gordon Guyatt, MD

18:21

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Recommendations About Screening: Interview With Gemma Louise Jacklyn

By Gemma Louise, BAppSc, MPH(Hons)

33:43

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How to Use a Noniferiority Trial: Interview With Dr Gordon Guyatt

By Gordon Guyatt, MD

21:26

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Clinical Prediction Rules: Interview With Dr Thomas G. McGinn

By Dr Thomas G. McGinn and Dr Edward Livingston

6:55

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The Process of a Systematic Review and Meta-analysis: M. Hassan Murad, MD, MPH, discusses the process of a systematic review and meta-analysis.

By Dr M Hassan Murad and Dr Edward Livingston

14:17

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The Origin of Evidence-Based Medicine and the Users' Guides to the Medical Literature: Gordon Guyatt, MD, MSc, explains the origin of the term "evidence-based medicine" and describes the Users' Guides to the Medical Literature and the benefits of applying the medical literature to clinical practice.

By Gordon Guyatt, MD, MSc

19:35

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Applying Evidence-Based Practice: Robert Hayward, MD, explains how clinicians can apply evidence-based medicine to their practices.

By Robert Hayward, MD

8:08

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The 5As of the Health Information Cycle: Robert Hayward, MD, defines the 5As of the health information cycle and helps learners understand the process.

By Robert Hayward, MD

10:46

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What is the Question? Gordon Guyatt, MD, MSc, discusses "Chapter 3: What Is the Question?" from the Users' Guides to the Medical Literature.

By Gordon Guyatt, MD, MSc

9:04

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Therapy (Randomized Trials): Gordon Guyatt, MD, MSc, discusses "Chapter 6: Therapy (Randomized Trials)" from the Users' Guides to the Medical Literature.

By Gordon Guyatt, MD, MSc

15:05

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The Process of Diagnosis: Gordon Guyatt, MD, MSc, discusses "Chapter 14: The Process of Diagnosis" from the Users' Guides to the Medical Literature.

By Gordon Guyatt, MD, MSc

10:51

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Summarizing the Evidence: Gordon Guyatt, MD, discusses "Chapter 19: Summarizing the Evidence" from the Users' Guides to the Medical Literature.

By Gordon Guyatt, MD

10:39

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Finding the Evidence: Ann McKibbon, MLS, PhD, discusses "Chapter 4: Finding the Evidence" from the Users' Guides to the Medical Literature.

By Ann McKibbon, MLS, PhD

9:00

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Randomized Trials Stopped Early for Benefit: Victor Montori, MD, discusses randomized trials that are stopped early for benefit.

By Victor Montori, MD

7:23

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N-of-1 Randomized Controlled Trials: Gordon Guyatt, MD, discusses n-of-1 randomized controlled trials.

By Gordon Guyatt, MD

14:57

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Measuring Patients' Experience: Toshi A. Furukawa, MD, PhD, discusses measuring patients' experience.

By Toshi A. Furukawa, MD, PhD

8:57

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Does Treatment Lower Risk? Roman Jaeschke, MD, MSc, discusses whether treatment lowers risk.

By Roman Jaeschke, MD, MSc

10:16

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Harm (Observational Studies): Mitchell Levine, MD, MSc, discusses harm (observational studies).

By Mitchell Levine, MD

7:52

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Philosophy of evidence-based medicine: Victor Montori, MD, discusses the philosophy of evidence-based medicine.

By Victor Montori, MD

19:34

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Prognosis: Adrienne Randolph, MD, MSc, discusses prognosis.

By Adrienne Randolph, MD, MSc

12:40

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Confidence Intervals: Gordon Guyatt, MD, discusses confidence intervals.

By Gordon Guyatt, MD

15:56

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Diagnostic Tests: Toshi A. Furukawa, MD, PhD, discusses diagnostic tests.

By Toshi A. Furukawa, MD, PhD

16:10

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Surprising Results of Randomized Trials: Gordon Guyatt, MD, surprising results of randomized trials.

By Gordon Guyatt, MD

10:38

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Why Study Results Mislead: Gordon Guyatt, MD, discusses bias, random error, and why study results sometimes mislead.

By Gordon Guyatt, MD

7:34

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Understanding the Results: More About Odds Ratios: Gordon Guyatt, MD, discusses odd ratios.

By Gordon Guyatt, MD

10:29

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Anthony J. Viera, MD, MPH, discusses the clinical examination for hypertension in adults.

By Anthony J. Viera, MD, MPH

12:40

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David Metcalfe, PhD, MRCP, MRCS, MRCEM, discusses the clinical examination for hip osteoarthritis.

By David Metcalfe, PhD, MRCP, MRCS, MRCEM

11:53

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Edward Etchells, MD, discusses the clinical examination for cardiac syncope.

By Edward Etchells, MD

16:36

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Michael E. Detsky, MD, MSHP, discusses the clinical examination for difficult intubation.

By Michael E. Detsky, MD, MSHP

15:42

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Charles J. Gerardo, MD, MHS, discusses the clinical examination for severe envenomation after snakebite.

By Charles J. Gerardo, MD, MHS

11:21

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David Meier, MD, and Tinh-Hai Collet, MD, discuss the clinical examination for acute mountain sickness with David L. Simel, MD.

By Meier David, MD

16:01

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Evan Wood, MD, PhD, FRCPC, discusses the clinical examination for severe alcohol withdrawal syndrome.

By Evan Wood, MD, PhD, FRCPC

19:34

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Sonal N. Shah, MD, MPH, discusses the clinical examination for childhood pneumonia.

By Sonal N. Shah, MD, MPH

09:35

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Peter Bentzer, MD, PhD, discusses the clinical examination for fluid responsiveness in hemodynamically unstable patients.

By Peter Bentzer, MD, PhD

14:12

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Evan Wood, MD, PhD, FRCPC, discusses the clinical examination for early HIV infection.

By Evan Wood, MD, PhD, FRCPC

15:03

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Sophiya Benjamin, MBBS, discusses the clinical examination for generalized anxiety or panic disorder.

By Sophiya Benjamin, MBBS

13:20

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Cynthia A. Moylan, MD, discusses the clinical examination for liver disease and cirrhosis.

By Cynthia A. Moylan, MD

20:13

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Job Hermans, MD, MSc, discusses the clinical examination for rotator cuff disease.

By Job Hermans, MD, MSc

09:05

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Kathryn A. Myers, MD, discusses the clinical examination for obstructive sleep apnea.

By Kathryn A. = Myers, MD

12:07

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Bryan Coburn, MD, PhD, discusses the clinical examination for bacteremia.

By Bryan Coburn, MD, PhD

12:21

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Delan Jinapriya, MD, FRCSC, discusses the clinical examination for primary open-angle glaucoma.

By Delan Jinapriya, MD, FRCSC

13:22

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Edward H. Livingston, MD, discusses the clinical examination for mononucleosis.

By Edward H. Livingston, MD

32:48

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Does This Women Have an Ectopic Pregnancy? Interview With Dr John R. Crochet

By John R. Crochet, MD

8:08

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Will Neuroimaging Reveal a Severe Intracranial Injury in This Adult With Minor Head Trauma? Interview With Joshua S. Easter, MD, MSc

By Joshua S. Easter, MD, MSc

24:55

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Does This Adult Patient Have Blunt Intra-abdominal Injury? Interview With Daniel K. Nishijima, MD, MAS

By Daniel K. Nishijima, MD, MAS

7:30

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Understanding How to Use Likelihood Ratios in Clinical Practice: A Conversation With the Rational Clinical Examination Editor, David L. Simel, MD, MHS

By David L. Simel, MD, MHS

14:47

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Acute Coronary Syndrome: Interview With Dr Alexander C. Fanaroff

By Alexander C. Fanaroff, MD

17:29

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Does This Older Adult With Lower Extremity Pain Have the Clinical Syndrome of Lumbar Spinal Stenosis?

By Pradeep Suri, MD

13:10

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Does This Patient Have Posttraumatic Stress Disorder? Interview With Dr Michele R. Spoont

By Michele R. Spoont, PhD

23:08

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Malaria: Interview With Dr Steve M. Taylor

By Dr Steve M. Taylor and Dr Edward Livingston

29:43

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F. Douglas Srygley, MD, and Dr David L. Simel, MD, MHS, discuss the clinical examination for upper gastrointestinal bleed.

By Dr F. Douglas Srygley, Dr David L. Simel, and Dr Edward Livingston

32:39

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Nadia A. Khan, MD, MSc, discusses the clinical examination for peripheral arterial disease.

By Dr Nadia A. Khan and Dr Edward Livingston

15:43

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Abnormal Central Venous Pressure: David L. Simel, MD, MHS, discusses the clinical examination for abnormal central venous pressure.

By David L. Simel, MD, MHS

7:05

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Does This Patient Have an Alcohol Problem?: Sheri A. Keitz, MD, PhD, discusses the rational clinical examination for alcohol abuse.

By Sheri A. Keitz, MD, PhD

11:42

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Peripheral Arterial Disease: Interview With Dr James M. Grichnik

By James M. Grichnik, MD, PhD

20:12

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The Rational Clinical Examination: David L. Simel, MD, explains the origin and development of The Rational Clinical Examination series and the value of this resource to learners and instructors.

By David L. Simel, MD

15:32

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Low Back Pain: Richard A. Deyo, MD, MPH, discusses the clinical examination for low back pain.

By Richard A. Deyo

9:15

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Osteoporosis: Cathleen Colón-Emeric, MD, MHSc, MD, MPH, discusses the clinical examination for osteoporosis.

By Cathleen Colón-Emeric, MD, MHSc, MD, MPH

7:26

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Urinary Tract Infection, Women: Stephen Bent, MD, discusses the clinical examination for urinary tract infections in women.

By Stephen Bent, MD

6:50

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Otitis Media, Child: Russell Rothman, MD, discusses the clinical examination for otitis media in children.

By Russell Rothman, MD

5:34

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Influenza: Lauren Brett Caram, MD, discusses the clinical examination for influenza.

By Lauren Brett Caram, MD

9:54

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Abdominal Aortic Aneurysm: Frank Lederle, MD, discusses the clinical examination for abdominal aortic aneurysm.

By Frank Lederle, MD,

4:09

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Dementia: Tracey Holsinger, MD, discusses the clinical examination for dementia.

By Tracey Holsinger, MD

6:17

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Adult Meningitis: Rose Hatala, MD, MSc, discusses the clinical examination for adult meningitis.

By Rose Hatala, MD, MSc

5:54

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Heart Failure: Bob Badgett, MD, discusses the clinical examination for heart failure.

By Bob Badgett, MD,

14:56

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Knee Ligaments and Menisci: Jeffrey Katz, MD, MSc, and Jonathan Schaffer, MD, MBA, discuss the clinical examination for diagnosing injuries to knee ligaments and menisci.

By Jeffrey Katz, MD, MSc and Jonathan Schaffer, MD, MBA

14:24

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Splenomegaly: David L. Simel, MD, MHS, discusses the clinical examination for splenomegaly. Please refer to Figure 46-1 and Figure 46-2 from The Rational Clinical Examination when listening to this podcast.

By David L. Simel, MD, MHS

8:48

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Pulmonary Embolism: Jeffrey Ginsberg, MD, FRCPC, discusses the clinical examination for pulmonary embolism.

By Jeffrey Ginsberg, MD, FRCPC

10:03

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Adult Appendicitis: James M. Wagner, MD, discusses the clinical examination for adult appendicitis.

By James M. Wagner, MD

12:15

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Deep Vein Thrombosis: Philip S. Wells, MD, MSc, discusses the clinical examination for deep vein thrombosis.

By Philip S. Wells, MD, MSc

9:10

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Cardiac Tamponade: Niteesh K. Choudhry, MD, PhD, discusses the clinical examination for cardiac tamponade.

By Niteesh K. Choudhry, MD, PhD

8:52

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Acute Cholecystitis: Robert L. Trowbridge, MD, discusses the clinical examination for acute cholecystitis.

By Robert L. Trowbridge, MD

5:25

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Myocardial Infarction: Akbar A. Panju, MBChB, FRCPC, discusses the clinical examination for myocardial infarction.

By Akbar A. Panju, MBChB, FRCPC

9:55

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Hepatomegaly: David L. Simel, MD, MHS, discusses the clinical examination for hepatomegaly.

By David L. Simel, MD, MHS

6:59

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Menopause: Lori A. Bastian, MD, MPH, discusses the clinical examination for menopause and perimenopause.

By Lori A. Bastian, MD, MPH

13:03

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Murmur, Systolic: Edward Etchells, MD, discusses the clinical examination for systolic murmurs.

By Edward Etchells, MD

8:28

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Goiter: Karen Barnard, MD, MPH, discusses the clinical exam for goiters.

By Karen Barnard, MD, MPH

4:51

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Breast Cancer: Mary B. Barton, MD, MPP, discusses the clinical examination for breast cancer.

By Mary B. Barton, MD, MPP

10:13

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Confidence Intervals: Gordon Guyatt, MD, discusses confidence intervals.

By Gordon Guyatt, MD

15:56

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Carotid Bruits: David L. Simel, MD, MHS, discusses the clinical examination for carotid bruits.

By David L. Simel, MD, MHS

9:19

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Airflow Limitation: David L. Simel, MD, MHS, discusses the clinical examination for airflow limitation.

By David L. Simel, MD, MHS

7:14

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Ascites: John W. Williams, Jr, MD, MHS, discusses the clinical examination for ascites.

By John W. Williams, Jr, MD, MHS

9:07

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Carpal Tunnel Syndrome: Richard S. Bedlack, MD, PhD, MS discusses the clinical examination for carpal tunnel syndrome.

By Richard S. Bedlack, MD, PhD, MS

5:19

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Clubbing: Kathryn A. Myers, MD, EdM, FRCPC, discusses the clinical examination for clubbing.

By Kathryn A. Myers, MD, EdM, FRCPC

9:38

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Sinusitis: John W. Williams, Jr, MD, MHS, discusses the clinical examination for sinusitis.

By John W. Williams, Jr, MD, MHS

7:02

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Abdominal Bruits: Sheri A. Keitz, MD, PhD, discusses the clinical examination for abdominal bruits.

By Sheri A. Keitz, MD, PhD

10:21

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New! Jane Armitage, MBBS, discusses the use of run-in periods in randomized trials.

By Jane Armitage, MBBS

19:28

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Matthew L. Maciejewski, PhD, discusses regression discontinuity design.

By Matthew L. Maciejewski, PhD

17:56

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Telba Z. Irony, PhD, discusses case-control studies.

By Telba Z. Irony, PhD

23:07

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Alex John London, PhD, discusses equipoise in research.

By John London, PhD

21:47

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Bayesian Analysis: Using Prior Information to Interpret the Results of Clinical Trials: Audio Interview With Melanie Quintana, PhD

By Melanie Quintana, PhD

27:30

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Gillian Sanders-Schmidler, PhD, provides an overview of cost-effectiveness analysis and how it is used to compare the relative costs, benefits, and harms of 2 or more interventions.

By Gillian Sanders-Schmidler, PhD

18:20

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Jing Cao, PhD, discusses multiple comparison procedures.

By Jing Cao, PhD

22:46

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William J. Meurer, MD, MS, and Juliana Tolles, MD, MHS, discuss the use of logistic regression model diagnostics to determine how well a model predicts outcomes.

By William J. Meurer, MD, MS, and Juliana Tolles, MD, MHS

32:47

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Roger J. Lewis, MD, PhD, discusses randomization in clinical trials, specifically in regards to permuted blocks and stratification.

By Roger J. Lewis, MD, PhD

23:13

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Susan S. Ellenberg, PhD, discusses stepped-wedge clinical trials and evaluation by rolling deployment.

By Susan S. Ellenberg, PhD

18:06

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Anna E. McGlothlin, PhD, discusses minimal clinically important difference and defining what really matters to patients.

By Anna E. McGlothlin, PhD

11:42

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Lynne Stokes, PhD, discusses sample size calculation for a hypothesis test.

By Lynn Stokes, PhD

12:13

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Harold C. Sox, MD, discusses pragmatic trials and how they can help address “real world” questions.

By Harold C. Sox, MD

21:17

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William J. Meurer, MD, MS, discusses cluster randomized trials and evaluating treatments applied to groups.

By William J. Meurer, MD, MS

23:41

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Kert Viele, PhD, discusses dose-finding trials and optimizing phase 2 data in the drug development process.

By Kert Viele, PhD

5:04

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Amy H. Kaji, MD, PhD, discusses noninferiority trials.

By Amy H. Kaji, MD, PhD

10:52

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Edward H. Livingston, MD, and Roger J. Lewis, MD, PhD, discuss the new JAMA Guide to Statistics and Methods book.

By Edward H. Livingston, MD

13:42

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Joanne Lynn, MD, MS, discusses the role of hospice and other services.

By Joanne Lynn, MD, MS

37:41

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Margot B. Kushel, MD, discusses end-of-life care for homeless patients.

By Margot B. Kushel, MD

22:52

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Paul B. Bascom, MD, discusses responding to requests for physician-assisted suicide.

By Paul B. Bascom, MD

15:49

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Daniel P. Sulmasy, OFM, MD, PhD, discusses spiritual issues in the care of dying patients.

By Daniel P. Sulmasy, OFM, MD, PhD

25:24

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Joshua M. Hauser, MD, discusses physician opportunities to support family caregivers at the end of life.

By Joshua M. Hauser, MD

25:12

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Harvey Max Chochinov, MD, PhD, FRSC, discusses dignity-conserving care at the end of life.

By Harvey Max Chochinov, MD, PhD, FRSC

22:25

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Psychological Considerations, Growth, and Transcendence at the End Of Life: Interview With Susan D. Block, MD

By Susan D. Block, MD

24:57

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James Hallenbeck, MD, discusses palliative care in the final days of life.

By James Hallenbeck, MD

22:56

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Sarah E. Harrington, MD, discusses the role of chemotherapy at the end of life.

By Harrington Sarah E., MD

16:07

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Sudden Traumatic Death in Children: Interview With Elaine C. Meyer

By Elaine C. Meyer, PhD, RN

36:48

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Caring for the Child With Cancer at the Close of Life

By Craig Hurwitz, MD

19:46

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Palliative Care for Patients With Head and Neck Cancer: Interview With Dr Nathan E. Goldstein

By Nathan E. Goldstein, MD

15:02

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Nathan E. Goldstein, MD, discusses how to talk to patients with limited life expectancy.

By Dr Nathan E. Goldstein and Dr Edward Livingston

26:53

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Elizabeth B. Lamont, MD, MS, discusses complexities in prognostication in advanced cancer.

By Dr Elizabeth B. Lamont and Dr Edward Livingston

29:05

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Hiroshi Mitsumoto, MD, DSc, discusses palliative care for patients with amyotrophic lateral sclerosis.

By Dr Hiroshi Mitsumoto and Dr Edward Livingston

10:31

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Overcoming the False Dichotomy of Curative vs. Palliative Care for Late-Stage HIV/AIDS: Peter A. Selwyn, MD, MPH, discusses the false dichotomy of curative vs palliative care for late-stage HIV/AIDS.

By Peter A. Selwyn, MD, MPH

10:45

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Practical Considerations in Dialysis Withdrawal: Lewis M. Cohen, MD, discusses practical considerations in dialysis withdrawal.

By Lewis M. Cohen, MD

6:45

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Palliative Care for Patients With Heart Failure: Steven Z. Pantilat, MD, discusses palliative care for patients with heart failure.

By Steven Z. Pantilat, MD

13:04

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Care at the Close of Life: Stephen J. McPhee, MD, and Margaret A. Winker, MD, discuss the new JAMAevidence book Care at the Close of Life: Evidence and Experience. Please refer to the JAMA Patient Page on palliative care when listening to this podcast.

By Stephen J. McPhee, MD and Margaret A. Winker, MD

14:09

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Initiating End-of-Life Discussions: Timothy E. Quill, MD, discusses initiating end-of-life discussions with seriously ill patients.

By Timothy E. Quill, MD

7:58

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Beyond Advance Directives: James A. Tulsky, MD, discusses moving beyond advance directives when communicating with patients at the end of life.

By James A. Tulsky, MD

8:50

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Decision Making: Stephen J. McPhee, MD, discusses decision making at a time of crisis near the end of life.

By Stephen J. McPhee, MD

12:58

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Conflict: Anthony L. Back, MD, discusses dealing with conflict in caring for the seriously ill.

By Anthony L. Back, MD

14:50

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Acute Pain Crisis: Natalie Moryl, MD, discusses managing an acute pain crisis in a patient with advanced cancer.

By Natalie Moryl, MD

6:35

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Dyspnea: John M. Luce, MD, discusses management of dyspnea in patients with far-advanced lung disease.

By John M. Luce, MD

5:15

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Intractable Nausea and Vomiting: Gordon J. Wood, MD, discusses the management of intractable nausea and vomiting in patients at the end of life.

By Gordon J. Wood, MD

12:04

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Palliative Care for Frail Older Adults: Kenneth S. Boockvar, MD, MS, discusses palliative care for frail older adults.

By Kenneth S. Boockvar, MD, MS

11:00

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Fatigue: Eduardo Bruera, MD, discusses palliative management of fatigue at the close of life.

By Eduardo Bruera, MD

8:32

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Advanced Metastatic Cancer: Janet L. Abrahm, MD, discusses spinal cord compression in patients with advanced metastatic cancer.

By Janet L. Abrahm, MD

11:22

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Agitation and Delirium: William Breitbart, MD, discusses agitation and delirium at the end of life.

By William Breitbart, MD

13:35

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Alzheimer disease: Ann C. Hurley, RN, DNSc, discusses Alzheimer disease.

By Ann C. Hurley, RN, DNSc

14:50

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